Newly discovered epidemiological evidence linking cholesteatoma to depression suggests that routine screening and monitoring of psychological status among cholesteatoma patients is warranted. Policies aimed at the early detection and timely treatment of comorbid depression following diagnosis with cholesteatoma could enhance health promotion and disease prevention.

The authors briefly summarize advances in the broad field of biochirality connecting two poles of the phenomena: the atomic orbitals and the brain’s cognitive function. Analysis of current results allows introducing the new generation of entangled biomarkers ranging from the molecular chirality to laterality of cognitive and executive functions.

The clinical pathologist/laboratory medicine physician serves as the ideal health care partner to synergize with the patient-physician-unit to temper curious results, obviate the “light switch” effect, provide guidance on current and emerging test utilization and management, navigate the DTC marketplace and educate patient and physician alike as required, and to ultimately incorporate lab test results into actual optimization of patient care. It is through this approach that the patient-physician-laboratorian triumvirate can maximize the experience to positively affect patient centric, evidenced based, fiscally responsible healthcare in the ever-changing medical landscape.

In every double blind clinical study of therapies, a certain percentage of subjects obtain the same benefit from a placebo, as with the real drug. Using today’s advanced brain imaging; we can identify the specific centers that supply the healing effect when it is a placebo. To augment therapy, reduce the amount of drug use and speed time of healing, the authors suggest to utilize the known principles of placebo physiology.

A comprehensive understanding of the mechanism underlying vertigo is essential to elucidate the reciprocal causal relationship between laryn-gopharyngeal reflux and Eustachian tube obstruction

This current review addresses the topic of therapeutic strategies for idiopathic SSNHL from the perspective of neuroplasticity. Assertions pertaining to the plausibility of this approach are based on a large body of evidence from animal experiments and recent studies on humans.