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Comparison of Inferior Turbinate Reduction Techniques on Postoperative Epistaxis and Nasal Congestion

Archives of Otorhinolaryngology-Head & Neck Surgery. 2022;6(1):1
DOI: 10.24983/scitemed.aohns.2022.00154
Article Type: Original Article

Abstract

Background: Inferior turbinate reduction is often performed concurrently during functional nasal surgery. Surgical techniques include partial excision and submucous resection. Common postoperative complications after nasal surgery include epistaxis and recurrent or persistent congestion.
Objective: The aim of the study was to determine the impact of inferior turbinate reduction technique on postoperative epistaxis and recurrent or persistent nasal congestion.
Methods: Patients who underwent nasal surgery at a single academic institution between January 2017 and December 2020 were identified. Data collected included demographics, risk factors, intraoperative techniques, and postoperative course. Main outcome measures were postoperative epistaxis and nasal congestion.
Results: Of the 219 nasal surgery patients who received concurrent inferior turbinate reduction, 146 (66.7%) underwent partial excision of the inferior-lateral aspect with a thru-cut and 73 (33.3%) underwent submucous resection using an ultrasonic bone aspirator (Stryker Sonopet®). Postoperative epistaxis and recurrent or persistent nasal congestion were not significantly associated with either inferior turbinate reduction technique.
Conclusion: A comparison of two methods of inferior turbinate reduction, partial excision and submucous resection, did not show a difference in risk of postoperative epistaxis or nasal congestion. Both techniques demonstrate safety and utility in inferior turbinate reduction.

Keywords

  • Epistaxis; inferior turbinate reduction; nasal congestion; nasal surgery; postoperative complications; submucous resection; ultrasonic bone aspirator

Introduction

Inferior turbinate hypertrophy is commonly found in patients with nasal obstruction and is often concurrent with septal deviation. Medical therapy for inferior turbinate hypertrophy includes an antihistamine or nasal decongestant spray [1]. If hypertrophied inferior turbinates are refractory to medical management, surgical reduction of the turbinates can be performed [2,3].

Several techniques exist for surgical inferior turbinate reduction. Submucous resection of the inferior turbinates involves removing the underlying bone and erectile tissue of the turbinates while sparing the mucosal tissue [4,5]. In contrast, partial excision of the inferior turbinates involves trimming portions of the inferior turbinate bone along with its overlying mucosa [4]. Both techniques are often performed in conjunction with outfracturing of the inferior turbinates, which lateralizes the entire turbinate structure and expands the internal nasal valve. Other surgical methods for inferior turbinate reduction include total turbinectomy, microdebrider removal, electrocautery, laser cautery, cryotherapy, and radiofrequency ablation [1,3-4,6-9].

Turbinate reduction surgery can be associated with adverse postoperative outcomes such as postoperative epistaxis, nasal congestion, infection, and nerve injury, and empty nose syndrome [4,10]. There is literature which comments on the rate of postoperative complications and the type of surgical technique utilized. For example, previous studies described rates of epistaxis to be 1.6% after submucous resection with a microdebrider and 5.8% after radical turbinectomy [9,11]. Other studies comment on nasal congestion: 96% of patients reported an improvement in nasal breathing two weeks after surgery, and 88% after two months, after undergoing bilateral inferior turbinate reduction. This was compared to 78% of patients who reported improvement after two weeks, and 76% after two months, after a submucosal diathermy turbinate reduction [12].

The purpose of this study was to compare two surgical techniques of inferior turbinate reduction, submucous resection versus partial excision, with their associated postoperative complications including epistaxis and recurrent nasal congestion in patients undergoing functional nasal surgery at a single academic center. To date, no other study has directly compared these two methods with endpoints of epistaxis and nasal congestion.

Methods

This study was approved by the Thomas Jefferson University Institutional Review Board. Retrospective identification of patients who underwent rhinoplasty with inferior turbinate reduction at a single academic institution between January 2017 and December 2020 was completed. Data collected included demographics, risk factors, intraoperative techniques, and postoperative clinical course. Each patient underwent rhinoplasty with inferior turbinate reduction completed one of two ways: a single surgeon utilized the submucous resection technique, and a second surgeon performed the partial excision technique. Patients were excluded from the study if they did not have a minimum follow-up of two months. This time period was chosen based on literature describing the assessment of nasal breathing after nasal surgery at the two-month mark [12]. Following this timeframe, a post-procedural period of less than two months was deemed inadequate to assess if the postoperative complications of interest did or did not occur. Therefore, patients lost to follow up prior to this time were excluded.

Inferior Turbinate Reduction Techniques
The first technique of inferior turbinate reduction was partial excision of the turbinate (Video 1). In this method, the turbinate is first in-fractured and the inferior-lateral aspect exposed. Starting from just posterior to the head of the turbinate, partial excision is performed with a thru-cut, progressively traveling posteriorly along the length of the turbinate. Hemostasis is achieved with suction bovie cautery, and the turbinate is then outfractured. The second technique is submucous resection of the turbinate, which requires a small incision at the head of the turbinate and elevation of a submucous pocket between the turbinate mucosa and underlying bone with a Cottle freer (Video 2). An ultrasonic bone aspirator (Stryker Sonopet®) is introduced into the pocket and bone is removed while sparing the turbinate mucosa. Similarly, the turbinate is then outfractured. Cautery is not regularly used with this technique. No postoperative nasal packing was utilized after either technique.

Outcome Measures
The primary outcome measures were postoperative epistaxis and recurrent or persistent nasal congestion. Epistaxis was defined as notable postoperative bleeding from the nasal cavity either reported by the patient or treated by a clinician. Recurrent or persistent nasal congestion was defined as excessive nasal congestion lasting longer than expected for a patient’s postoperative period of two months. The “excessive” nature of the congestion was a subjective assessment reported by the patient. Predictors analyzed included patient age, gender, body mass index (BMI), smoking status, history of previous nasal surgery, history of nasal trauma, concurrent septoplasty, and presence of prolonged nasal crusting or empty nose syndrome. Smoking status was defined as never, former, or current smoker. History of previous nasal surgery included history of turbinate reduction or turbinectomy, functional endoscopic sinus surgery (FESS), rhinoplasty, open reduction internal fixation (ORIF) for nasal fracture, or septoplasty. Prolonged nasal crusting was defined as crusting of the nasal cavity examined via fiber-optic scope lasting longer than expected for the postoperative timeframe as deemed by the surgeon. Empty nose syndrome was defined as a paradoxical subjective complaint of nasal congestion, dryness, or crusting without objective physical evidence of obstruction within the nasal cavity.

Statistical Analysis
For the statistical analyses, SPSS version 27 software (IBM Corp., Armonk, NY, USA) was used. Univariable analysis was performed on the primary endpoints of epistaxis and recurrent or persistent nasal congestion with predictors using a logistic regression model. Statistical significance was defined as a P-value <0.05.

Results

Three hundred and eight patients underwent functional nasal surgery involving inferior turbinate reduction during the selected timeframe. Of those 308 patients, 219 met the two-month postoperative follow-up criteria and were included in the analysis. One hundred and forty-six (66.7%) underwent inferior turbinate reduction via the partial excision technique, and 73 (33.3%) underwent inferior turbinate reduction via the submucous resection method. Patient demographics within each group are demonstrated in Table 1. There were no reports of prolonged nasal crusting or empty nose syndrome. The average follow-up period was 12.41 months ± 11.53 months.

 

 

Epistaxis
For the cohort that underwent partial excision, 7 (4.8%) patients experienced postoperative epistaxis. For the cohort that received submucous resection, 2 (2.7%) patients experienced postoperative epistaxis (P = 0.37 on Fischer’s exact test). Never-smokers had a lower probability of epistaxis compared to current smokers (odds ratio = 0.079, 95% confidence interval = 0.010-0.592, P = 0.014). All other predictors including patient age, gender, BMI, smoking status (former vs. current and former vs. never), history of previous nasal surgery, history of nasal trauma, concurrent septoplasty, and performing surgeon were insignificant using univariable logistic regression model and are demonstrated in Table 2. Other risk factors, specifically diabetes (2 out of 219, 0.9%), coagulation abnormalities (1 out of 219, 0.45%), and the use of anticoagulation or antiplatelet medications (8 out of 219, 3.65%) were not included in this analysis due to the low number of subjects.

 

 

Nasal Congestion
For the cohort that received partial excision, 34 (23.3%) patients experienced postoperative recurrent or persistent nasal congestion. For the cohort that received submucous resection, 17 (23.3%) patients experienced postoperative recurrent or persistent nasal congestion (P = 0.57 using univariable logistic regression). All other predictors including patient age, gender, BMI, smoking status, history of previous nasal surgery, history of nasal trauma, concurrent septoplasty, and performing surgeon were insignificant using univariable logistic regression model and are demonstrated in Table 3. Hence none of the predictors were retained in the multivariable logistic regression model. Other risk factors, specifically diabetes, coagulation abnormalities, and the use of anticoagulation or antiplatelet medications, were not included in this analysis due to the low number of subjects.

 

 

Discussion

Inferior turbinate reduction is commonly performed during rhinoplasty and functional endoscopic sinus surgery to provide symptomatic relief of nasal congestion. There are numerous studies which describe the types of surgical procedures used to perform turbinate reduction and the possible postoperative complications. Established methods used to address turbinate hypertrophy include, but are not limited to, electrocautery, microdebridement, laser, diathermy, and submucosal resection. Currently, there is literature which assesses these techniques and the rates of different postoperative sequelae. For example, Majahan et al. compared the technique of powered turbinectomy with a microdebrider to submucous resection using turbinate scissors and reported decreased epistaxis and persistent nasal obstruction in the submucous resection cohort [13]. Currently, there is limited data comparing two particular techniques of turbinate reduction performed at our institution: partial excision and submucous resection. In the study described in this paper, retrospective review of 219 patients at a single academic center who underwent inferior turbinate reduction demonstrated that neither method was associated with an increased risk of postoperative epistaxis or differences in outcomes of recurrent or persistent nasal congestion.

Bleeding after turbinate reduction is a well-studied complication after nasal surgery. A retrospective review of 359 patients who underwent septoplasty with turbinate reduction cited a 4.5% rate of postoperative epistaxis [5]. However, the etiology of epistaxis was described as multifactorial and dependent on different variables including concurrent nasal procedures such as septoplasty, method of turbinate reduction, and use/non-use of nasal packing. A separate review reported that the most common postoperative complications for patients who underwent partial excision of the inferior turbinates included crusting (20% of patients) and rhinorrhea (11% of patients) [4]. Another study analyzing 120 patients who underwent submucous resection of the inferior turbinates using a microdebrider found a postoperative bleeding rate of 1.6% [9]. There is limited data comparing bleeding rates after partial turbinate excision versus submucous turbinate resection, and our results suggest no difference in bleeding outcomes depending on the technique utilized.

Current smokers had a significantly higher amount of epistaxis episodes as a cohort compared to never-smokers in our study (P = 0.014). There is a known association between smoking and increased risk of postoperative bleeding after otolaryngologic surgery. An explanation for the relationship between tobacco smoke and postoperative bleeding is tobacco smoke acting as a chemical irritant, and toxins within the smoke irritating fragile vessels prone to rupture which leads to bleeding. A prospective cohort study by Langsted et al. discusses how smoking is associated with increased risk of major bleeding specifically airway, urinary, gastrointestinal and intracranial bleeding. The presence of smoking and intensity of smoking increased the risk of major bleeding, which supports our finding of current smokers experiencing significantly more episodes of epistaxis than never-smokers [14-16].

Recurrent or persistent nasal congestion after turbinate reduction is another well-established sequelae of nasal surgery, particularly turbinate reduction. Neumann et al. conducted a study which surveyed patients’ nasal aeration, sense of smell, rhinorrhea, and sense of smell after septoplasty and turbinate reduction. Preoperatively, 93% of patients rated their nasal obstruction as moderate (37.23%) or severe (56.2%). Postoperatively, 35.29% of patients still reported a small degree of nasal breathing obstruction [17]. Gupta et al. found that patients rated the severity of daytime nasal obstruction as 2.3 out of 6 after resection of the inferior and lateral aspects of the inferior turbinate using a microdebrider [18]. Other studies reported similar changes in nasal airway obstruction over various timeframes [19]. Our results demonstrated a similar percentage of postoperative nasal obstruction: 17.2% of patients total, 17.4% for the partial resection technique and 16.8% for the submucous resection technique, experienced postoperative recurrent or persistent nasal congestion. A study by Hol et al. discussed how certain turbinate reduction techniques including turbinectomy and partial resection via cutting and/or trimming were less successful than submucous techniques due to the altered turbinate mucosa [20]. This particular paper suggested complete or partial removal of turbinate mucosa can cause persistent nasal congestion due to ‘renewed hyperplasia’ of the mucosa and be associated with decreased success in relieving obstruction over time. Interestingly, this contrasts with our findings in that there was no difference in rate of postoperative nasal congestion between the partial excision (mucosal-sacrificing) and submucous resection with Sonopet (mucosal-preserving) techniques.

The rationale for conducting this study was to compare two methods of minimally invasive inferior turbinate reduction methods used at our institution using the outcome measures of postoperative epistaxis and nasal congestion. A review of current literature did not reveal established studies comparing these two techniques and the outcomes of interest. Additionally, it is worth highlighting that several of the aforementioned studies included nasal packing in their cohorts, which differs from our study design, and could affect rates of postoperative epistaxis and congestion [13,5]. Our rates of epistaxis and nasal congestion after turbinate reduction were similar to what has been described in the literature. However, our results are unique in that they show no difference in postoperative complication rate between two surgical techniques which have not previously been compared. This supports the novel nature and utility of this study.

Limitations
The main limitations of this study are the retrospective nature of data collection and the subjectivity of perceived nasal congestion. Retrospective data collection through patient medical charts allows for outcomes such as epistaxis and recurrent or persistent nasal congestion to be recorded only when mentioned by the patient and documented by a healthcare professional. It is possible there were other episodes of recurrent nasal congestion extending past the follow-up period average of 12.41 months ± 11.53 months that were not reported by the patient. Longer follow-up would allow for detection of persistent or recurrent nasal congestion as well as delayed presentations of epistaxis. Another confounding factor is the additional procedures often performed in conjunction with turbinate reduction to address functional aspects of nasal congestion. Turbinate reduction as an isolated procedure was rare among our patient population, therefore epistaxis and nasal congestion as postoperative complications cannot be solely attributed to the turbinate reduction procedure. Finally, as a single center study the derived results may be less generalizable despite the large sample size.

Future Directions
In the future, it would be beneficial to investigate these endpoints in a prospective nature with a defined follow-up period. This would allow for a more definitive and informed evaluation of recurrent nasal congestion. With a prospective study design, rhinomanometry, a functional test of nasal aerodynamics that measures transnasal airflow and pressure gradient, could be completed after inferior turbinate reduction for quantitative analysis and comparison of the two techniques [21].

Conclusion

The goal of this study was to evaluate postoperative complications that can occur after two techniques of inferior turbinate reduction, i.e., partial excision of the inferior-lateral aspect with a thru-cut and submucous resection with an ultrasonic bone aspirator (Stryker Sonopet®). Our study found no statistical difference between the two techniques in the rate of postoperative epistaxis or recurrent nasal obstruction. Never-smokers had a decreased rate of epistaxis overall. These findings demonstrate that both techniques have reasonable clinical utility with low rates of postoperative epistaxis.

References

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Editorial Information

Publication History

Received date: October 10, 2021
Accepted date: December 14, 2021
Published date: January 14, 2022

Author Contributions

Emily S. Sagalow contributed to the design, data collection, analysis, writing/editing of the manuscript; Vanessa Christopher contributed to the writing/editing of the manuscript; Kurren Gill contributed to the design, writing/editing of the manuscript; Raphael Banoub contributed to the data collection of the manuscript; Somya Shankar contributed to the data collection of the manuscript; Madalyne Sunday contributed to the data collection of the manuscript; Tingting Zhan contributed to the analysis of the manuscript; Glen D’Souza contributed to the analysis and the writing/editing of the manuscript; Joel Stanek contributed to the design and the writing/editing of the manuscript; Michelle Hwang contributed to the writing/editing of the manuscript; Ryan Heffelfinger contributed to the design and the writing/editing of the manuscript; Howard Krein contributed to the design and the writing/editing of the manuscript.

Ethics Approval and Consent to Participate

The study is in accordance with the ethical standards of the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Funding

This research received no specific grant from any funding agency in the public, commercial, or not-for-profit sectors.

Conflict of Interest

The authors report no financial or other conflict of interest relevant to this article, which is the intellectual property of the authors.

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Department of Otolaryngology-Head and Neck Surgery, Thomas Jefferson University Hospital, Philadelphia, PA, USA
Department of Otolaryngology-Head and Neck Surgery, Thomas Jefferson University Hospital, Philadelphia, PA, USA
Department of Otolaryngology-Head and Neck Surgery, Thomas Jefferson University Hospital, Philadelphia, PA, USA
Department of Otolaryngology-Head and Neck Surgery, Thomas Jefferson University Hospital, Philadelphia, PA, USA
Department of Otolaryngology-Head and Neck Surgery, Thomas Jefferson University Hospital, Philadelphia, PA, USA
Department of Otolaryngology-Head and Neck Surgery, Thomas Jefferson University Hospital, Philadelphia, PA, USA
Division of Biostatistics, Department of Pharmacology and Experimental Therapeutics, Thomas Jefferson University Hospital, Philadelphia, PA, USA
Department of Otolaryngology-Head and Neck Surgery, Thomas Jefferson University Hospital, Philadelphia, PA, USA
Department of Otolaryngology-Head and Neck Surgery, Thomas Jefferson University Hospital, Philadelphia, PA, USA
Department of Otolaryngology-Head and Neck Surgery, Thomas Jefferson University Hospital, Philadelphia, PA, USA
Department of Otolaryngology-Head and Neck Surgery, Thomas Jefferson University Hospital, Philadelphia, PA, USA
Department of Otolaryngology-Head and Neck Surgery, Thomas Jefferson University Hospital, Philadelphia, PA, USA
Department of Otolaryngology-Head and Neck Surgery, Thomas Jefferson University Hospital, Philadelphia, PA, USA

Address: 925 Chestnut Street, Floor 6, Philadelphia, PA 19107, USA
Table 1.jpgCharacteristics of Patients and Surgical Procedures

Table 2.jpgUnivariate Analysis of Predictors for Postoperative Epistaxis

Table 3.jpgUnivariate Analysis of Predictors for Recurrent or Persistent Nasal Congestion

Video 1. Partial excision of the inferior-lateral aspect with a thru-cut

Video 2. Submucous resection by an ultrasonic bone aspirator

Reviewer 1 Comments

  1. Selection of predictors is important for unilateral and multivariate analyses. Overlapping of predictors and outcome variables may cause a severe confounding effect. In my opinion, presence of prolonged nasal crusting and empty nose syndrome are postoperative consequences that may be associated with the outcome measures in the study, i.e., postoperative epistaxis and recurrent or persistent nasal congestion. I wonder if it is proper to select prolonged nasal crusting or empty nose syndrome to be one of the predictive variables.
    ResponseNo patients experienced prolonged nasal crusting or empty nose syndrome, so this was not included in the predictive variables. This is clarified in the Results section.
     
  2. In the Method section, the authors defined recurrent or persistent nasal congestion as excessive nasal congestion lasting longer than expected for a patient’s postoperative period of 3 months. However, “excessive” is quite subjective, and it remains unclear how “excessive” is defined by the patients. Was there any measurement tool (for instance, 10-point rating scale) used in the research to quantitatively define excessive nasal congestion?
    ResponseThere was no measurement tool such as a 10-point rating scale used to quantitively define excessive nasal congestion. “Excessive” nasal congestion was defined subjectively by speaking with the patient.
     
  3. Were all the surgeries performed by the same surgeon? If not, I believe “surgeon” may be one of the important confounders that may be associated with the outcomes, and the factor should be included in the logistic regression analyses.
    ResponseThe surgeries were performed by two separate surgeons. This was added to the Methods section and included in the analysis. In our study we aim to compare the difference in rates of postoperative epistaxis and patient-perceived nasal congestion after undergoing partial resection of turbinates (as practiced by surgeon 1) vs submucous resection of turbinates (as practiced by surgeon 2).

Reviewer 2 Comments

  1. Were there any patients excluded from the study? Authors must specify the criteria used for the exclusion of participants in study group and control group.
    ResponsePatients who followed up for less than two months postoperatively were excluded from the study. Two months was chosen as the study timeframe based on literature describing improvement in nasal symptoms after surgery. Therefore, it was felt that patients who did not follow up for at least two months after surgery did not have an adequate postoperative period to definitively conclude the endpoints of interest did or did not occur. This is mentioned in the Methods section.
     
  2. The observation period should be of sufficient duration to allow for the occurrence of significant changes or events. How long was the follow-up period in the study? This should be mentioned in the Result section.
    ResponseThe average follow-up period of the study was added in the Results section. The dataset was updated and now the average follow-up period was 12.41 months ± 11.53 months.
     
  3. The underlying diseases such as diabetes or coagulation abnormalities may be associated with postoperative epistaxis. These data need to be mentioned in the Material section, and these factors should be analyzed as outcome predictors.
    ResponseThere was a low “N” when totaling the number of patients with diabetes, coagulation abnormalities, and the use of anticoagulation or antiplatelet drugs. Therefore, this was not added to the analysis as outcome predictors. This is stated in the Results section.
     
  4. The material or method used for postoperative nasal packing may be associated with postoperative bleeding. If it was different in the two groups, this factor should be included as one of the predictive variables.
    ResponseThere was no postoperative nasal packing used for any patients. This clarification was added to the Methods section.

Reviewer 3 Comments

  1. In the study, recurrent or persistent nasal congestion was defined as excessive nasal congestion lasting longer than expected for a patient’s postoperative period of 3 months. The authors should clarify how the 3-month period was defined? Is it a literature-based variable?
    ResponseAfter further review of current literature, we found many patients are seen in follow up about two months after nasal surgery. It is felt by this time, patients are out of the perioperative window and can clearly report on postoperative complications and the status of their nasal breathing. Therefore, we altered our postoperative period to two months. Although this eliminated 89 patients from our original cohort, we felt this time frame was a more accurate representation of the typical post-operative follow-up timeline. This is mentioned in the Methods section.
     
  2. In the study limitation section, it was mentioned “It is possible there were other episodes of epistaxis or nasal congestion extending past the follow up period average of 5.7 months ± 7.2 months that were not reported by the surgeon.” Is it correct that the standard deviation (7.2 months) is longer than the outcome period (5.7 months)?
    ResponseYes, that is correct. The follow-up period was updated and now the average was 12.41 months ± 11.53 months.
     
  3. Regarding postoperative nasal bleeding, it seems that there is limited data comparing bleeding rates after partial turbinate excision versus submucous turbinate resection, and the results in the study suggest no difference in bleeding outcomes depending on the technique utilized. Regarding recurrent or persistent nasal congestion after turbinate reduction, nevertheless, research outcomes (i.e., predictors of postoperative nasal congestion) were not compared with those obtained in previous studies. Possible explanations should also be proposed in cases where the current findings are inconsistent with those in the literature.
    ResponseThere are studies which individually compare the turbinate reduction techniques we describe to other surgical methods, however there were no studies found which directly compared the two. Also, such studies included additional factors such as postoperative nasal packing, which differs from our study design. Finally, there is research which comments on the techniques we mention and their associated postoperative epistaxis and nasal congestion, however they do so without a comparison group. These comparisons and referenced studies were added to the Discussion section.

Reviewer 4 Comments

  1. The authors should specify the rationale of conducting the study to justify the significance and novelty of the study. In particular, postoperative consequences associated with inferior turbinate reduction have been well-studied previously. The authors may further clarify the reason to extend the research in this topic and may provide a brief review of the literature addressing the potentially relevant issues, including (1) limitations and/or flaws in previous studies, (2) unresolved gaps in the research, or (3) contradictory outcomes between studies.
    ResponseThis is elaborated upon in the Discussion section. The rationale of conducting this study was to compare two main methods of minimally invasive inferior turbinate reduction methods used at our institution using the outcome measures of postoperative epistaxis and nasal congestion. Our rates of epistaxis and nasal congestion after turbinate reduction were similar to what has been described in the literature. However, our results are unique in that they show no difference in postoperative complication rate between two methods which have not previously been compared. This supports the novel nature and utility of this study.
     
  2. In the Introduction section, in addition, more relevant background studies may be added to describe the current state of research in that particular field, i.e., comparison of postoperative consequences of turbinate reduction surgeries.
    ResponseMore relevant background studies were added to the Introduction section to further describe the current state of research in this field.
     
  3. Please clarify if there were any patients lost to follow-up or excluded from the study?
    ResponsePatients who followed up for less than two months postoperatively were excluded from the study. Two months was chosen as the study timeframe based on literature describing improvement in nasal symptoms after surgery. Therefore, it was felt that patients who did not follow up for at least two months after surgery did not have an adequate postoperative period to definitively conclude the endpoints of interest did or did not occur. This is mentioned in the Methods section.

Sagalow ES, Christopher V, Gill K, Banoub R, Shankar S, Sunday M, Zhan T, D'Souza G, Stanek J, Hwang M, Heffelfinger R, Krein H. Comparison of inferior turbinate reduction techniques on postoperative epistaxis and nasal congestion. Arch Otorhinolaryngol Head Neck Surg. 2022;6(1):1. https://doi.org/10.24983/scitemed.aohns.2022.00154