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Advancing Breast Reconstruction: Next-Generation Robotic-Assisted Deep Inferior Epigastric Perforator Flap Techniques

International Microsurgery Journal. 2024;8(1):3
DOI: 10.24983/scitemed.imj.2024.00185
Article Type: Review Article

Abstract

Robotic-assisted surgery has revolutionized the surgical world, introducing innovative methods to reduce invasiveness across a variety of procedures. Despite its promise, the adoption of robotic-assisted techniques in microsurgery has been gradual. Many microsurgical procedures traditionally rely on open approaches and demand a level of technical skill that exceeds the current capabilities of robotic systems. The robotic-assisted deep inferior epigastric perforator (DIEP) flap for breast reconstruction exemplifies a pioneering application of robotic technology that enhances the "gold standard" for flap-based breast reconstruction. This technique enables microsurgeons to harvest the pedicle of the abdominal flap with a significantly shorter fascial incision. It is hypothesized that minimizing the fascial incision length could mitigate donor site morbidity and related complications, such as core weakening, pain, and the risk of fascial bulge or hernia. This manuscript delves into the robotic-assisted DIEP flap, elaborating on the operative technique and sharing critical surgical insights necessary for successful implementation. Furthermore, it reviews the pertinent literature, underscoring both the successes and potential areas for enhancement of the robotic-assisted DIEP flap. This comprehensive examination showcases the current advancements and sets the stage for future innovations in the field of robotic-assisted microsurgery.

Keywords

  • Abdominal muscles; breast reconstruction; mammaplasty; microsurgery; perforator flap; robotics; surgery

Robotic-Assisted Surgery Overview

Robotic-assisted surgery (RAS) was first conceptualized in the 1980s by Scott Fisher at the National Aeronautics and Space Administration (NASA) and Joseph Rosen, a plastic surgeon at Stanford University [1]. Originating as a derivative of laparoscopic surgery, RAS aims to improve surgical outcomes through minimally invasive approaches, thereby reducing human error [2]. Since the introduction of early robotic equipment such as the Programmable Universal Machine for Assembly (PUMA) Arm and RoboDoc, designed for neurologic and orthopedic surgery respectively, to the advent of the da Vinci® System, the field of RAS has experienced exponential growth over the past decades [1,2].

The da Vinci® System, which consists of a surgeon’s console equipped with cameras for each eye, a patient trolley with four articulated arms, and an advanced imaging system, was the first surgical robot to receive FDA approval in 2000 [2,3]. It has been widely adopted across various medical subspecialties, including urology, gynecology, otolaryngology, cardiothoracic, and abdominal surgery [4–6]. Research on outcomes in these fields has underscored the significant benefits of RAS for both patients and providers.

Benefits and Advancements in RAS

RAS has been shown to minimize morbidity and mortality by reducing risks associated with surgical tremor and fatigue, providing seven degrees of motion, and offering three-dimensional vision, thereby enhancing the surgeon’s dexterity and the visualization of the surgical field [6]. Given that the initial surgical robot was developed with clinical input from Joseph Rosen, a plastic surgeon, specifically to enhance neurovascular anastomoses in hand surgery, RAS has consistently demonstrated significant potential within the field of plastic surgery [1]. Its swift adoption in otolaryngology, particularly through transoral robotic surgery, exemplifies one way RAS has penetrated plastic surgery [7]. Research on transoral robotic surgery has shown it facilitates easier dissection, reduces damage to adjacent anatomy, and improves both visualization and ergonomics for surgeons [7–9].

RAS in Plastic Surgery

Similarly, the success of RAS in oncology has spurred the development of robotic techniques for nipple sparing mastectomy [9–13]. Studies have revealed that when RAS is applied to the harvesting of flaps, particularly the latissimus dorsi and deep inferior epigastric perforator (DIEP) flaps, it enhances visualization and reduces surgical complications and scarring [13–16]. Additionally, RAS has highlighted the benefits of tremor filtration and motion scaling in creating effective and successful anastomoses [13,17]. Head and neck and breast reconstructions are two areas where RAS can greatly improve both the surgical experience and outcomes, offering substantial advancements in plastic surgery.

Case Presentation

The authors report on a 63-year-old postmenopausal female patient with a documented history of moderately differentiated invasive ductal carcinoma in the left breast. The tumor tested positive for estrogen and progesterone receptors (ER+/PR+), and negative for the human epidermal growth factor receptor 2 (HER2-). It was staged as pT2N0 under the tumor, node, metastasis (TNM) classification system and classified as Stage 1B according to the American Joint Committee on Cancer (AJCC) standards.

She underwent a skin-sparing mastectomy of the left breast and prepectoral tissue expander reconstruction with an acellular dermal matrix. Neoadjuvant anastrozole was required, but adjuvant radiation therapy was not administered. Following the completion of her oncologic care, she expressed concerns about deformity, asymmetry, and mastodynia in her reconstructed breast.

Consequently, she showed interest in autologous breast reconstruction and decided to undergo a delayed microsurgical reconstruction of the left breast using a robotic-assisted right DIEP flap. This decision was informed by a detailed discussion of her options and preferences, taking into account her surgical history and insights from magnetic resonance angiogram scans.

For the robotic-assisted DIEP approach, preoperative imaging is essential for perforator mapping, selection, and assessment of the intramuscular course of the pedicle. The ideal candidate typically displays a single perforator or two grouped perforators in close proximity with a short intramuscular course. Analysis of the length of the intramuscular course is crucial for determining candidacy, as the fascial incision must extend the entire length of the pedicle’s intramuscular course at a minimum. For this patient, the magnetic resonance angiogram revealed two notably large perforators, making her a suitable candidate for this advanced surgical technique.

Operative Technique

Preoperative Marking and Initial Dissection
The donor and recipient sites were marked preoperatively while the patient was in the upright position (Figure 1A). The robotic-assisted DIEP flap technique began with the elevation of the abdominal flap, with dissection performed down to the anterior rectus fascia, similarly to the conventional open approach. The right abdominal donor site flap was elevated centrally from lateral to medial, with direct undermining based on the selected perforators identified by preoperative imaging (Figure 1B). Lateral perforators were clipped and ligated until two large medial row perforators were identified.

Once the pre-selected perforators were exposed, the anterior rectus fascia was minimally incised. The pedicle was then traced to the retromuscular position, and at this point, the remainder of the dissection was performed submuscularly (Figure 1C). The vertical length of the fascial incision was limited to the region through which the pedicle runs intramuscularly. In this case, a separate perforator was in close proximity to the perforator of interest along the same medial row, and therefore the fascial incision was extended to expose both perforators (Figure 1D). Despite this extension, the overall length of the incision did not preclude the robotic-assisted approach. Notably, a nerve graft may be performed for coaptation after the DIEP flap is harvested (Figure 1E).

 

Figure 1. Preoperative marking and initial dissection. (A) Preoperative markings for a 63-year-old female with a history of left breast cancer, scheduled for delayed left breast microsurgical reconstruction utilizing a robotic-assisted right deep inferior epigastric artery perforator (DIEP) flap. (B) The targeted perforator is successfully identified and exposed, facilitated by preoperative magnetic resonance angiography. (C) The procedure identifies a single dominant perforator, optimal for the robotic-assisted DIEP flap harvest approach. Notably, an additional perforator is observed in proximity to the primary target along the same medial row. (D) A minimal extension of the fascial incision is performed to expose both perforators. Despite this extension, the incision's length remains conducive to the robotic-assisted approach. Once exposed, meticulous dissection is conducted following the pedicle to the submuscular plane. (E) A nerve graft is executed for coaptation following the harvesting of the DIEP flap.

 

Securing and Preparing the DIEP Flap
Once the pedicle was dissected posterior to the rectus muscle, a vessel loop was loosely secured around the pedicle from the open, anterior exposure (Figure 2A). The loop was then channeled and nestled in the submuscular plane to facilitate robotic-assisted retrieval of the vessel loop intraperitoneally. To allow insufflation of the abdomen, Bacitracin ointment covered with Xeroform gauze was used as a temporary seal to minimize the escape of gas from the fascial defect. This seal was also temporarily reinforced with sutures (Figures 2B–D).

To ensure that the pedicle was not compromised after establishing a seal, the skin paddle of the abdominal flap was checked for adequate perfusion through assessment of color, capillary refill, and audible Doppler signal. The entire left hemi-abdominal flap was elevated prior to robotic-assisted dissection so that the flap was solely reliant on its right two perforators. After an adequate seal was established and the left hemi-abdominal flap was elevated, Size 0 Vicryl sutures were used to secure the DIEP flap and robotic-assisted access into the peritoneal cavity was performed (Figures 2E–F).

 

Figure 2. Securing and preparing the deep inferior epigastric perforator (DIEP) flap. (A) A red vessel loop is circumferentially secured around the pedicle and gently tunneled into the submuscular plane. Intra-abdominally, the vessel loop aids in pedicle retrieval and minimizes the risk of pedicle injury during robotic-assisted dissection. To mitigate gas leakage from the external defect during insufflation, Bacitracin ointment (B), Xeroform gauze dressing (C), and two size 0 polydioxanone (PDS) sutures (D) are applied sequentially. The sutures are strategically placed above and below the perforator. (E) Size 0 Vicryl sutures are employed to secure the DIEP flap during insufflation. (F) Size 0 Vicryl sutures are also utilized to reflect the superior flap, allowing for optimal robotic docking.

 

Bilateral DIEP Flap Considerations
In bilateral DIEP flap procedures, it is crucial to preserve the superior continuation of the perforator in the hemi-abdominal flap that is scheduled for secondary recipient site microsurgery. Alternatively, a separate perforator from the second transposed hemi-abdominal flap can be exposed, preserved, and maintained in situ based on the opposite row to ensure adequate perfusion of the flap. This is done after the pedicle of the primary perforator of interest has been clipped and ligated with robotic assistance intra-abdominally. The second perforator or the superior continuation of the perforator in the second hemi-abdominal flap is ligated once the second flap is prepared for microsurgical anastomosis. This careful preservation and management of perforators are essential to ensure the viability and successful integration of both flaps during the bilateral DIEP flap procedure.

Robotic DIEP Flap Procedure
At our institution, at this point in the procedure, a general surgeon with advanced skills in robotic techniques assumes the lead. The interdisciplinary nature of our team, which includes general surgeons, enables us to safely dissect the vascular pedicle robotically.

An open Hasson entry technique was utilized to access the peritoneal cavity, though a Veress needle could alternatively be used. After inserting an AirSeal port (CONMED, Utica, NY, USA), pneumoperitoneum was established at a pressure of 10–15 mmHg. A camera was then placed through the insufflation port to assist in the insertion of three additional 8-mm robotic ports. These ports were inserted above the umbilicus through the fascia at the level of the epigastrium, in a manner similar to the robotic transabdominal preperitoneal (rTAPP) repair for inguinal hernias (Figure 3A). 

Alternatively, the contralateral ports relative to the targeted DIEP flap may be placed lateral to the semilunar line and along an imaginary line connecting the anterior superior iliac spine and the anterior axillary line, with the middle port positioned between the anterior superior iliac spine and the anterior axillary line. This approach necessitates undocking of the robot when switching to the contralateral side during a bilateral DIEP procedure, which reduces overall efficiency compared to the previously described approach that allows for single docking when harvesting both pedicles.

Monopolar scissors and fenestrated bipolar graspers initiated the intraperitoneal dissection of the pedicle (Figure 3B). The peritoneum was incised lateral to the lateral umbilical fold until the previously positioned vessel loop was visualized and retrieved. This vessel loop was then manipulated to aid in the dissection of the pedicle up to its proximal origin at the level of the external iliac vessels. Microclips and bipolar graspers were employed to sever all contributing side branches until the pedicle was substantially freed (Figure 3C).

Following thorough dissection, the pedicle was clipped, cut, and detached from the external iliac vessels (Figures 3D–E). The pedicle was then divided distally and completely removed through the external fascial opening. A detailed video supplement demonstrating the robotic-assisted extraction of the vascular pedicle in a DIEP flap procedure is available at https://doi.org/10.24983/scitemed.imj.2024.00185. This video clearly illustrates the removal process from the intra-abdominal cavity.

 

Figure 3. Robotic-assisted deep inferior epigastric perforator (DIEP) flap procedure. (A) Port placement mimics the approach used in robotic transabdominal preperitoneal (rTAPP) repair for inguinal hernia, with pneumoperitoneum established at a pressure of 10–15 mmHg. (B) Monopolar scissors and a fenestrated bipolar grasper are utilized to incise the peritoneum. The red vessel loop is retrieved intra-abdominally to facilitate optimal pedicle dissection. (C) All contributing side branches are either clipped using microclips or ligated with the bipolar device to ensure clear pedicle dissection. (D) Microclips are applied to the pedicle near its proximal origin at the level of the external iliac vessels. (E) After clipping, monopolar scissors are used to cut the pedicle at its base.

 

Video Following robotic-assisted ligation, the vascular pedicle of the deep inferior epigastric perforator flap is externally extracted and removed from the intra-abdominal cavity.

 

Closure and Final Steps
Robotic-assisted closure of the posterior rectus sheath was carried out, followed by the undocking of the robotic arms from the patient (Figure 4A). The pneumoperitoneum was then decompressed, and the port sites were closed using figure-of-eight sutures. The operation proceeded as a traditional DIEP procedure with the closure of the small external fascial defect after the flap had been removed and readied for microsurgical anastomosis (Figures 4B–D).

 

Figure 4. Closure and final steps. (A) A barbed suture is used to robotically close the posterior rectus sheath in a running fashion. (B) The isolated abdominal flap after the pedicle is completely ligated and removed through the external fascial defect. (C) Closure of the external fascial defect shows a defect length confined to less than 5 cm. (D) Immediate postoperative result.

Robotic DIEP Reconstruction Evolution

To fully appreciate the current applicability and future potential of robotic-assisted DIEP flap breast reconstruction, it is crucial to understand its historical context. Autologous breast reconstruction has gained popularity, as numerous studies have shown it leads to higher patient satisfaction, fewer long-term complications, and superior aesthetic outcomes compared to implant-based reconstructions [18,19]. The DIEP flap has become the “gold standard” for breast reconstruction. While other flaps, such as thigh and trunk-based flaps, are also viable options, the DIEP flap is particularly advantageous due to the abundant availability of donor tissue in the abdominal area [20].

The main drawback of the DIEP flap is that the surgeon must create a lengthy fascial incision to harvest the pedicle. These fascial openings sometimes extend below the arcuate line, leaving patients more susceptible to significant postoperative pain, abdominal weakening, fascial bulge, or hernia [21,22]. Dr. Jesse Selber pioneered the robotic-assisted DIEP flap in the last decade to offer the benefits of autologous breast reconstruction with the DIEP flap while minimizing invasiveness [14]. With the robotic-assisted DIEP flap technique, the fascial incision only needs to extend as long as the pedicle’s intramuscular course. The remainder of the pedicle is harvested intra-abdominally using robotic assistance. This approach significantly reduces the length of the fascial incision, theoretically lowering the risk for significant pain and the aforementioned donor site complications.

Promising Robotic DIEP Outcomes

While the robotic-assisted DIEP flap represents a relatively new advancement in microsurgical breast reconstruction, it has already shown promising clinical outcomes. In 2022, Selber and colleagues published a preliminary case series involving 21 patients who underwent robotic-assisted DIEP flap breast reconstruction [12]. This cohort had a mean fascial incision length of 3.6 ± 1.6 cm, significantly shorter than the traditional 13 cm incision associated with the standard DIEP technique. The mean pedicle length for this group was 13.3 ± 1 cm, and none of the patients developed bulges or hernias. Although the study’s small sample size precludes definitive conclusions about complication rates, the reduction in fascial incision length without compromising pedicle length is notable.

Other institutions have also documented early success with the robotic-assisted DIEP flap technique. Lee et al. published an article reporting significantly lower levels of postoperative pain in patients who underwent robotic-assisted DIEP flap breast reconstruction compared to those who had traditional DIEP flap surgery [16]. Wittesale et al. conducted a retrospective review of outcomes at their institution and found no flap failures or intra-abdominal complications among 10 patients who received robotic-assisted DIEP flaps. They noted a steep learning curve associated with the robotic-assisted DIEP technique; although it did not impact the success of the surgeries, the operative time was significantly longer than that required for traditional DIEP flaps [23]. Furthermore, Daar et al. reported on a series involving four patients who underwent robotic-assisted DIEP flaps, with none experiencing flap loss or abdominal site complications [24]. While clinical outcome studies are still limited, initial reports consistently affirm the clinical viability and safety of the robotic-assisted DIEP flap technique, showing promising signs of improved postoperative outcomes.

Current Limitations

Limitations in Patient Eligibility
The promising early success of robotic-assisted DIEP flap breast reconstruction is not without its limitations. A significant limitation of the current technique is that not all patients are ideal candidates. As previously discussed, if preoperative imaging shows a patient’s vascular anatomy to have a long intramuscular course, a longer fascial incision is required, reducing the benefits of the robotic-assisted technique. Currently, there is no method to harvest the pedicle with an incision shorter than the length of the pedicle’s intramuscular course [25]. This restricts the number of patients who can benefit from this advanced surgical method.

Technical Challenges and Port Setup
Additionally, the technology used in RAS involves a complex port setup. Multiple port sites are currently required, and for some bilateral procedures, the robotic system must be repositioned for each side [14]. Efficiency and invasiveness could be improved by reducing the number of necessary ports and eliminating the need for repositioning. The technical limitations of the robotic system can partially be attributed to its relatively new application in harvesting robotic-assisted DIEP flaps. Although it has been demonstrated that RAS can safely provide more minimally invasive breast reconstructions, the systems were not originally designed with this specific technique in mind. As the robotic-assisted DIEP flap, and more broadly, robotic microsurgical procedures, continue to be recognized for their superior outcomes, it is likely that robotic surgical systems will evolve to allow more seamless technical integration.

TAPP Versus TEP Approaches
There are two techniques that can be used for the robotic-assisted DIEP flap: the transabdominal preperitoneal (TAPP) approach and the totally extraperitoneal (TEP) approach. This paper focuses on the TAPP approach, with which we have experienced significant initial success at our institution. The TAPP approach offers several advantages over the TEP approach, including shorter operative times and a simpler learning curve. However, it is crucial to discuss the drawbacks of the TAPP approach, notably its more invasive nature due to the need to enter the intraabdominal cavity. Additionally, this technique presents a higher barrier to entry, particularly for plastic surgeons who are not proficient in intraabdominal procedures.

Conversely, the TEP approach provides completely extraperitoneal access to the vascular pedicle. Although the advantages of the TEP approach are well-documented, its steep learning curve and longer operative times have limited its widespread adoption for robotic-assisted DIEP flap harvest [26]. Manrique et al. conducted a cadaveric study comparing the TAPP and TEP approaches, validating the feasibility of both methods and confirming their theoretical advantages and limitations [27]. Further studies are essential to determine the most advantageous approach, enabling surgeons to refine and master a preferred technique.

Cost and Operative Time Considerations
The most significant drawback of the robotic-assisted DIEP flap technique is the increased cost and operative time. Firstly, the upfront cost of a robotic surgical system is substantial, and for institutions that do not already own one, this can be a considerable barrier [28,29]. Even if an institution already has a robotic surgical system or the upfront cost is not an issue, the robotic-assisted DIEP flap requires significantly longer operative times compared to the traditional DIEP flap. This increase in operative time results in higher hospital and anesthesia fees; however, reimbursement rates for robotic-assisted and traditional DIEP flaps are the same [30].

While studies are being conducted to analyze the overall cost-effectiveness of the robotic-assisted DIEP flap technique, there remains uncertainty as to whether the initial investment in operative time and cost is justified in the long term [31,32]. However, analysis of cost-effectiveness in other specialties suggests promising results. For example, Leow et al. reported that robotic-assisted prostatectomies could reduce overall hospital expenses compared to traditional radical open prostatectomies by decreasing time spent in the intensive care unit and shortening hospital stays [33]. Furthermore, Rodrigues Martins et al. showed that experience plays a significant role in improving cost-effectiveness, providing further incentive to develop effective multidisciplinary training protocols [34].

Future Directions for Robotic DIEP flap

Advancing Robotic DIEP Flap Efficiency
For the robotic-assisted DIEP flap technique to continue gaining popularity and acceptance, refining the technique and preparing the next generation of surgeons are crucial. Enhancing the port setup required for robotically harvesting the pedicle of the DIEP flap could significantly improve the efficiency of the procedure. Currently, the technique requires multiple robotic port sites and frequent repositioning of the surgical robot in bilateral cases.

Further research and validation of single-port techniques are essential. Advancements in robotic technology that enable bilateral pedicle harvesting without repositioning could make surgeries less invasive. These innovations would also significantly reduce operative times, improving overall surgical efficiency and patient outcomes. While there are promising studies indicating major improvements in robotic surgical systems [6,35], these advancements have yet to be applied and validated for the robotic-assisted DIEP flap technique. Moreover, robotic surgical systems designed for microsurgery are rapidly evolving. As these systems with enhanced technical capabilities become more widely available, it is conceivable that procedures currently unsuitable for RAS, such as vascular anastomosis and nerve reinnervation, could also be performed robotically.

To address the issues of increased operative time and costs associated with the robotic-assisted DIEP flap technique, enhancing the operative efficiency of surgeons is key. Research indicates that even minor improvements to the operating room setup and coordination can significantly boost surgical efficiency [36,37]. Additionally, the noted steep learning curve associated with this technique underscores the importance of surgeons gaining proficiency and comfort with the necessary robotic technology and procedures [12,23]. Dr. Selber has advocated for the expansion of plastic surgery residency curriculums to include training in RAS [38], highlighting the critical need for hands-on experience.

Interdisciplinary Programs for Training
The development of interdisciplinary programs is vital. These initiatives should enable general surgeons with advanced robotic training to instruct residents, fellows, and practicing plastic surgeons. Such programs could drastically accelerate the learning process, enabling surgeons to achieve peak operational efficiency more swiftly. Furthermore, by educating and training the next generation of surgeons in robotic techniques, institutions may be more inclined to invest in robotic surgical technology, thereby enhancing the accessibility of advanced methods like the robotic-assisted DIEP flap.

Conclusions

The introduction of the DIEP flap has significantly transformed the options available for women considering breast reconstruction. Although it is considered the “gold standard” for autologous breast reconstruction, the traditional DIEP flap is invasive and may result in lengthy abdominal fascial incisions, which can lead to increased pain, bulging, and hernias. The robotic-assisted DIEP flap marks the next advancement in this field, providing all the advantages of traditional DIEP flap reconstruction while reducing morbidity at the donor site. While the robotic-assisted approach currently involves longer operative times and higher costs, there are numerous potential improvements that could alleviate these disadvantages. The robotic-assisted DIEP flap is a crucial development in enhancing the surgical experience for women undergoing breast reconstruction.

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Editorial Information

Publication History

Received date: March 12, 2024
Accepted date: May 09, 2024
Published date: June 03, 2024

Disclosure

The manuscript has not been presented or discussed at any scientific meetings, conferences, or seminars related to the topic of the research.

Ethics Approval and Consent to Participate

The study adheres to the ethical principles outlined in the 1964 Helsinki Declaration and its subsequent revisions, or other equivalent ethical standards that may be applicable. These ethical standards govern the use of human subjects in research and ensure that the study is conducted in an ethical and responsible manner. The researchers have taken extensive care to ensure that the study complies with all ethical standards and guidelines to protect the well-being and privacy of the participants.

Funding

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Division of Plastic and Reconstructive Surgery, Northwell Health, Zucker School of Medicine at Hofstra/Northwell, Great Neck, NY, USA
Division of Plastic and Reconstructive Surgery, Northwell Health, Zucker School of Medicine at Hofstra/Northwell, Great Neck, NY, USA
Division of Plastic and Reconstructive Surgery, Northwell Health, Zucker School of Medicine at Hofstra/Northwell, Great Neck, NY, USA
Division of Plastic and Reconstructive Surgery, Northwell Health, Zucker School of Medicine at Hofstra/Northwell, Great Neck, NY, USA
Department of Plastic Surgery, Corewell Health, Grand Rapids, MI, USA
Division of Plastic and Reconstructive Surgery, Northwell Health, Zucker School of Medicine at Hofstra/Northwell, Great Neck, NY, USA
Division of Plastic and Reconstructive Surgery, Northwell Health, Zucker School of Medicine at Hofstra/Northwell, Great Neck, NY, USA
Division of Plastic and Reconstructive Surgery, Northwell Health, Zucker School of Medicine at Hofstra/Northwell, Great Neck, NY, USA
Email: ntanna@northwell.edu
Address: 600 Northern Boulevard, Suite 310, Great Neck, NY 11021, USA
Figure 1.png
Figure 1. Preoperative marking and initial dissection. (A) Preoperative markings for a 63-year-old female with a history of left breast cancer, scheduled for delayed left breast microsurgical reconstruction utilizing a robotic-assisted right deep inferior epigastric artery perforator (DIEP) flap. (B) The targeted perforator is successfully identified and exposed, facilitated by preoperative magnetic resonance angiography. (C) The procedure identifies a single dominant perforator, optimal for the robotic-assisted DIEP flap harvest approach. Notably, an additional perforator is observed in proximity to the primary target along the same medial row. (D) A minimal extension of the fascial incision is performed to expose both perforators. Despite this extension, the incision
Figure 2.png
Figure 2. Securing and preparing the deep inferior epigastric perforator (DIEP) flap. (A) A red vessel loop is circumferentially secured around the pedicle and gently tunneled into the submuscular plane. Intra-abdominally, the vessel loop aids in pedicle retrieval and minimizes the risk of pedicle injury during robotic-assisted dissection. To mitigate gas leakage from the external defect during insufflation, Bacitracin ointment (B), Xeroform gauze dressing (C), and two size 0 polydioxanone (PDS) sutures (D) are applied sequentially. The sutures are strategically placed above and below the perforator. (E) Size 0 Vicryl sutures are employed to secure the DIEP flap during insufflation. (F) Size 0 Vicryl sutures are also utilized to reflect the superior flap, allowing for optimal robotic docking.
Figure 3.png
Figure 3. Robotic-assisted deep inferior epigastric perforator (DIEP) flap procedure. (A) Port placement mimics the approach used in robotic transabdominal preperitoneal (rTAPP) repair for inguinal hernia, with pneumoperitoneum established at a pressure of 10–15 mmHg. (B) Monopolar scissors and a fenestrated bipolar grasper are utilized to incise the peritoneum. The red vessel loop is retrieved intra-abdominally to facilitate optimal pedicle dissection. (C) All contributing side branches are either clipped using microclips or ligated with the bipolar device to ensure clear pedicle dissection. (D) Microclips are applied to the pedicle near its proximal origin at the level of the external iliac vessels. (E) After clipping, monopolar scissors are used to cut the pedicle at its base.
Figure 4.png
Figure 4. Closure and final steps. (A) A barbed suture is used to robotically close the posterior rectus sheath in a running fashion. (B) The isolated abdominal flap after the pedicle is completely ligated and removed through the external fascial defect. (C) Closure of the external fascial defect shows a defect length confined to less than 5 cm. (D) Immediate postoperative result.

Video Following robotic-assisted ligation, the vascular pedicle of the deep inferior epigastric perforator flap is externally extracted and removed from the intra-abdominal cavity.

Peer Review Report: Round 1

Editor's Comments

Robotic-assisted surgery has established a presence in specialties such as gynecology, urology, and general surgery; however, its integration into plastic surgery has lagged. This review substantially enhances the sparse literature on robotic techniques within the field of plastic surgery. Importantly, it features a comprehensive case study that elucidates the procedural steps executed by the surgical team, thereby rendering these advanced surgical methods more accessible and understandable to plastic surgeons. This enhancement facilitates the broader adoption of next-generation robotic-assisted Deep Inferior Epigastric Perforator (DIEP) flap harvest techniques. The article is timely and possesses significant potential to advance the field of plastic surgery, meriting extensive discussion and scrutiny within the clinical community. Upon addressing reviewers' concerns, this pivotal article could have a profound impact on the realm of breast reconstruction surgery.
ResponseThank you for this recognition of the importance of our manuscript.

Reviewer 1 Comments

This article represents a substantial advancement in the field of breast reconstruction by exploring the application of robotic-assisted surgery in the harvesting of Deep Inferior Epigastric Perforator (DIEP) flaps. It effectively demonstrates how integrating robotic technology can enhance the efficiency of flap harvesting processes, potentially reducing operative times, minimizing morbidity, and improving both aesthetic and functional outcomes. The article provides detailed descriptions of the procedures, as well as preoperative and postoperative considerations, forming a thorough guide that could significantly shape future surgical techniques. Additionally, the included case study offers practical insights into the challenges and solutions associated with implementing robotic systems in complex reconstructive surgeries. This innovative approach, combined with an in-depth analysis, positions the article as a significant contribution to the existing literature on robotic surgical applications, establishing a new standard for excellence in breast reconstruction and encouraging further research. Nonetheless, certain issues must be addressed to further solidify the findings and implications of this study.

  1. The review currently lacks a discussion on two prominent robotic-assisted DIEP surgery methods: the totally extraperitoneal (TEP) and the transabdominal preperitoneal (TAPP) approaches. It is recommended that the authors include a detailed comparative analysis of these techniques, underscoring common advantages such as smaller incisions and reduced postoperative pain compared to the conventional open approach. Additionally, the narrative should highlight the TAPP approach's shorter operative times and simpler learning curve. Unlike the longitudinal dissection required by their natural orientation, the TAPP approach facilitates lateral dissection of the deep inferior epigastric vessels. However, it is crucial to discuss the TAPP approach’s drawbacks, such as its more invasive nature due to the need for peritoneal incisions to accommodate robotic arm access, which could pose challenges for surgeons less experienced with abdominal procedures. Incorporating references to pertinent studies, such as Manrique et al. (J Reconstr Microsurg. 2020;36:362–368), which utilized cadavers to compare these methods, would significantly enrich the review. This study provides essential insights into the procedural specifics of both approaches, yet it does not cover factors like the need to establish hemostasis and the additional time and potential complications involved, which are critical considerations in surgical comparisons.
    ResponseWe agree that an improved comparison of the TEP and TAPP approaches would benefit our manuscript. We have now added a paragraph to the “current limitations,” where the TEP approach had previously been mentioned, that details advantages and drawbacks of both approaches. We specify that in this manuscript we detailed the TAPP approach and highlight improvements to both approaches that could benefit patients.
     
  2. The authors note that while ongoing studies are assessing the cost-effectiveness of the robotic DIEP flap technique, it remains unclear whether the higher initial costs and extended operative times are justified in the long term. This concern is valid; however, a more balanced discussion is warranted. Robotic surgery is often perceived as more expensive compared to open or laparoscopic approaches, amid debates over its relative health benefits. Nevertheless, numerous studies indicate that the higher costs may be offset by favorable clinical outcomes, such as reduced need for blood transfusions, shorter hospital stays, and fewer perioperative complications. For instance, Leow et al. highlighted that robotic surgery might result in lower overall hospital costs compared to open surgery by reducing time spent in the ICU and hospital stays (Leow et al., Eur Urol 2016;70(5):837–45). Furthermore, the findings by Rodrigues Martins et al. suggest that surgical experience plays a significant role in cost management, demonstrating that increased proficiency and teamwork can reduce operation times and enhance cost-effectiveness, particularly in more experienced centers (Rodrigues Martins et al., Int J Med Robot. 2021 Dec;17(6):e2311). Therefore, it is crucial to consider these potential long-term benefits against the initial expenses in a balanced discussion on the financial implications of robotic-assisted surgeries.
    ResponseWe appreciate this suggestion and agree that these are two excellent resources to highlight the long-term payoff of increased initial cost of robotic surgery. Discussion and reference to these two papers have now been added to the “current limitations” section.
     
  3. In robotic-assisted DIEP flap surgeries, it is essential for surgeons to have advanced skills in robotic techniques to prevent damage to the critical vascular pedicle. In this case report, it is crucial for the authors to specify whether the surgery was performed by surgeons skilled in robotic procedures. This clarification could significantly influence how the results are interpreted.
    ResponseThis is an excellent point. Further clarification has been added to the operative technique description, making clear at which point our general surgery colleagues take the lead. Clarification was also added to the second paragraph of the “future steps to success” section to show the interdisciplinary nature of training between general surgeons and plastic surgeons that would be most effective for the adoption robotic surgery.

Reviewer 2 Comments

The review article begins with an overview of recent advancements in breast reconstruction, particularly highlighting the application of robotic assistance in harvesting Deep Inferior Epigastric Perforator (DIEP) flaps. It presents a detailed analysis of the associated surgical procedures, augmented by a case study that demonstrates the practical implementation of this technology in reconstructive surgery. However, the research exhibits significant limitations, including the lack of standardized preoperative evaluations and ambiguous criteria for participant selection, which undermine its impact. Furthermore, the article does not address nerve preservation or conduct a comprehensive cost-benefit analysis of robotic versus traditional surgical methods—essential components for enhancing its clinical relevance and scholarly value. It is advisable for the authors to address these shortcomings to improve the manuscript’s suitability for publication.

  1. The discussion on the standardization of protocols for preoperative DIEP evaluation in the article remains incomplete, which complicates the optimization of surgical preparation. The article highlights the essential role of preoperative imaging in determining candidates for robotic DIEP surgery. It notes that ideally, suitable patients exhibit one or two closely situated perforators with a short intramuscular trajectory. The authors are encouraged to provide a clearer rationale for these selection parameters, specifically addressing whether they aid in limiting the fascial incision to the extent of the perforator’s intramuscular path. Additionally, could the authors provide data, based on these criteria and their clinical experiences, on the proportion of patients deemed suitable for robotic DIEP surgery?
    ResponseThank you for this critique. Your assumption is correct; identifying patients whose vascular anatomy has a short intramuscular course is critical because this acts as the limiting factor to how small the fascial incision can be. The fascial incision must, at a minimum, extend the length of the vascular pedicle’s intramuscular course because this part of the dissection is completed using an open technique before the robot is set up. The robotic technique can only be used to dissect the submuscular portion of the pedicle. For this reason, patients whose vascular pedicle has a short intramuscular course are more ideal candidates for the robotic DIEP flap as they can obtain maximal benefit of a limited fascial incision. Further clarification regarding this point has been added to the case presentation section, with more detailed explanation included in the “history of the robotic DIEP flap” section.
     
  2. In breast reconstruction, particularly with DIEP flap procedures, the potential of robotic-assisted surgery to enhance sensory innervation requires further exploration. Preservation of breast sensibility is crucially dependent on the integrity of the 3rd to 6th intercostal nerves and the supraclavicular branches of the cervical plexus. Traditional surgical methods often risk severing these nerves during mastectomy, which can significantly impair the patient's quality of life and self-esteem by diminishing the sensory integration of the reconstructed breast. This inquiry seeks to determine whether robotic-assisted techniques can precisely harvest and preserve these critical sensory branches within the skin paddle of the reconstructed breast, thus facilitating effective reinnervation. This issue warrants further investigation. Detailed insights into the technological capabilities of robotic systems for this specific task would be invaluable for advancing the field.
    ResponseThis is an important point. Further discussion of the technical capabilities and shortcomings of the current iteration of robotic surgical systems has been added to the second paragraph of the “current limitations” section. Regarding the first point made by reviewer 2, the current robotic systems being used for the robotic DIEP flap do not allow robotic reinnervation. However, this is an extremely interesting future direction as microsurgical robotic systems continue to improve, and discussion of this possibility has been added to the future directions section.
     
  3. The authors highlight that the robotic-assisted DIEP flap procedure typically necessitates a longer operative duration compared to the traditional DIEP flap procedure, which contributes to increased hospital and anesthesia costs. However, the reimbursement rates for both robotic and traditional methods remain identical. To substantiate this assertion, referencing empirical data is crucial. For instance, Gundlapalli et al. reported in a case study that the total charge for a patient undergoing the robotic-assisted procedure was comparable to the average cost of traditional non-robotic cases within their practice—$16,300 versus $14,800, respectively (Gundlapalli et al., Microsurgery. 2018 Sep;38(6):702–705). This comparison underscores the financial implications of adopting robotic technology in surgical practices and highlights the necessity for a detailed cost analysis to better understand the economic impact relative to traditional methods.
    ResponseThis is an excellent resource, and it is now referenced in the discussion of cost in the “current limitations” section.

Editorial Comments

  1. The description of the patient's medical condition in the manuscript lacks critical details. The authors present a case involving a 63-year-old female with a history of left breast cancer, who underwent a left breast skin-sparing mastectomy followed by prepectoral tissue expander reconstruction using an acellular dermal matrix. However, they omit essential information, such as the cancer's stage, whether the patient received chemoradiotherapy, the specific timing of her breast reconstruction post-mastectomy, and her follow-up protocols. This information is crucial for assessing the potential indications for DIEP flap breast reconstruction and serves as important criteria for selecting similar patients for this procedure.
    ResponseWe agree that this was an oversight on our part. Further details on the patient’s medical history including her cancer stage and previous oncological treatments are now included in the “case presentation” section.
     
  2. The use of abbreviations in article titles can diminish clarity and reduce accessibility, especially for readers unfamiliar with the specific terminology. To better convey both the innovative nature and the specificity of the content, the following title may be considered: Advancing Breast Reconstruction: Next-Generation Robotic-Assisted Deep Inferior Epigastric Perforator Flap Techniques.
    ResponseThank you for this suggestion. We agree and the article title has been updated accordingly.
     

Peer Review Report: Round 2

Editorial Comments

  1. Following preliminary editorial feedback, the authors expanded the "case presentation" section of their manuscript, claiming to add details about the patient's cancer stage and previous oncological treatments. Nevertheless, a subsequent evaluation revealed that the cancer stage, a critical element, was absent in the updated submission.
    ResponseThank you for this feedback. To add further details to the case presentation, we went back and reviewed the patient’s chart. There is now a much more comprehensive description of the patient’s cancer stage at the time of surgery as well as previous oncological treatments.
     
  2. In reference 19, the title appears as a blend of English and a non-English language: "Patient satisfaction after breast reconstruction: implants vs. autologous tissues. Spokojenost pacientek po rekonstrukci prsu: implantáty versus autologní tkáně." Authors are advised to verify if their citation refers to the following article: Fracon S, Renzi N, Manara M, et al. Patient satisfaction after breast reconstruction: implants vs. autologous tissues. Acta Chir Plast. 2018; 59:120–128. [Article Link].
    ResponseThank you for pointing out this error. We verify that the article referenced by the reviewer is correct, and have updated reference 19 with the correct citation.

Aiello C, Choe J, Suri K, Smith ML, Selber JC, Sugiyama G, Tanna N. Advancing breast reconstruction: Next-generation robotic-assisted deep inferior epigastric perforator flap techniques. Int Microsurg J. 2024;8(1):3. https://doi.org/10.24983/scitemed.imj.2024.00185